What is the relationship between body weight changes and ghrelin secretion?

• A. Direct correlation
• B. Inverse correlation
• C. No correlation
• D. Unpredictable

Answer: (B)

The relationship between body weight changes and ghrelin secretion is characterized by an inverse correlation. Ghrelin is often referred to as the "hunger hormone" and is produced primarily by the stomach. Its secretion increases when the body is in a state of energy deficit, such as during weight loss or fasting, stimulating appetite and food intake. Conversely, when there is weight gain and an abundance of energy reserves, ghrelin levels tend to decrease.

This mechanism helps regulate body weight by signaling the body to eat more when there is a caloric deficit and to reduce intake when energy stores are sufficient. Thus, the fluctuations in ghrelin secretion are reflective of the body's energy needs and weight status, leading to the inverse relationship; as body weight increases, ghrelin secretion decreases, and vice versa.