What is the primary purpose of hormone replacement therapy in children with Prader-Willi syndrome after they reach the hyperphagic stage?

• A. Prevent giantism
• B. Prevent weight loss
• C. Prevent short stature
• D. Prevent muscle rigidity

Answer: (C)

The primary purpose of hormone replacement therapy in children with Prader-Willi syndrome after they reach the hyperphagic stage is to prevent short stature. This syndrome often leads to growth hormone deficiency, which can result in significantly reduced growth and ultimately shorter stature when compared to peers. By administering growth hormone, the therapy aims to stimulate growth and development in children, thereby helping them reach a more typical height as they progress through childhood and adolescence.

While some of the other options may seem relevant to the management of Prader-Willi syndrome, such as concerns about weight management or muscle tone, the most significant reason for hormone replacement therapy in this context is to support normal growth and prevent short stature, making it essential for their overall physical development.