What gut hormone is known to facilitate digestion by stimulating secretion of peptidases from the pancreas?

• A. CCK
• B. Gastrin
• C. Secretin
• D. Insulin

Answer: (A)

The correct choice is CCK, or cholecystokinin. This hormone plays a crucial role in the digestive process by facilitating the digestion of fats and proteins. CCK is secreted by the intestinal cells in response to the presence of fatty acids and amino acids in the small intestine. One of its main functions is to stimulate the secretion of digestive enzymes, including peptidases, from the pancreas. These enzymes are essential for breaking down proteins into smaller peptides and amino acids, which can then be absorbed by the body.

In addition to stimulating enzyme secretion from the pancreas, CCK also aids in stimulating the gallbladder to release bile, which helps emulsify fats for better absorption. This dual action supports effective digestion and nutrient absorption.

While gastrin primarily stimulates acid secretion in the stomach, secretin mainly regulates the pH levels in the small intestine by stimulating bicarbonate secretion from the pancreas, and insulin is involved in glucose metabolism rather than protein or fat digestion. Therefore, CCK is the hormone specifically recognized for its role in promoting peptidase secretion and facilitating digestion.